47589-M

Mitomycin C, Streptomyces caespitosus

• 同義詞: Mitomycin C, Streptomyces caespitosus, Mitocin C, MMC
• 經驗公式（希爾表示法）: C₁₅H₁₈N₄O₅
• CAS號碼: 50-07-7
• 分子量：: 334.33
• MDL號碼: MFCD00078109
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥95% (HPLC)
• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: blue-violet
• 溶解度: water: 1 mg/mL
• 儲存溫度: 2-8°C
• InChI: 1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
• InChI 密鑰: NWIBSHFKIJFRCO-WUDYKRTCSA-N

描述

一般說明

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues, disrupting base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G₂ phase.

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

外觀

Provided as 2 mg antibiotic and 48 mg NaCl.

重構

Following reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.

其他說明

Kruyt, F.A., et al. 1996. Blood 89, 938.
Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst.87, 1394.
Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
Kawasaki, S., et al. 1992. Jpn. J. Cancer Res.83, 899.
Malkinson, A.M., et al. 1992. Cancer Res.52, 4752.
McEvoy, J.L., et al. 1992. J. Bacteriol.174, 5471.
Tomasz, M., et al. 1987. Science235, 1204.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS08,GHS07
• 訊號詞: Warning
• 危險聲明: H302,H351
• 防範說明: P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Carc. 2
• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable