472804

S-Methyl-L-thiocitrulline, Dihydrochloride

A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

• 同義詞: S-Methyl-L-thiocitrulline, Dihydrochloride, N ^δ-(S-Methyl)isothioureido-L-ornithine, N^δ-(S-Methyl)isothioureido-L-ornithine
• 經驗公式（希爾表示法）: C₇H₁₅N₃O₂S · 2HCl
• CAS號碼: 209589-59-3
• 分子量：: 278.20
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white to off-white
• 溶解度: water: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C7H15N3O2S/c1-13-7(9)10-4-2-3-5(8)6(11)12/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12)/t5-/m0/s1
• InChI 密鑰: NGVMVBQRKZPFLB-YFKPBYRVSA-N

描述

一般說明

A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

A cell-permeable, inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

生化／生理作用

Cell permeable: yes

Primary Target
Rat neuronal nitric oxide synthase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 300 nM for rat neuronal nitric oxide synthase

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他說明

Krishnaswamy, N., et al. 1995. J. Biol. Chem.270, 11103.
Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.
Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem.37, 885.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3