454202

8-Methoxymethyl-3-isobutyl-1-methylxanthine

A cell-permeable selective inhibitor of Ca²⁺-calmodulin-dependent phosphodiesterase (PDE I; IC₅₀ = 4 µM).

• 同義詞: 8-Methoxymethyl-3-isobutyl-1-methylxanthine, 8-Methoxymethyl-IBMX
• 經驗公式（希爾表示法）: C₁₂H₁₈N₄O₃
• CAS號碼: 78033-08-6
• 分子量：: 266.30
• MDL號碼: MFCD00211081
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white
• 溶解度: ethanol: 2 mg/mL; DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 10-30°C
• InChI: 1S/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14)
• InChI 密鑰: NBLBCGUCPBXKOV-UHFFFAOYSA-N

描述

一般說明

A cell-permeable selective inhibitor of Ca²⁺-calmodulin-dependent phosphodiesterase (PDE I; IC₅₀ = 4 µM).

A cell-permeable, selective inhibitor of Ca²⁺-calmodulin-dependent phosphodiesterase (PDE I, IC₅₀ = 4 µM).

生化／生理作用

Cell permeable: yes

Primary Target
PDE 1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4 µM against Ca2+-calmodulin-dependent phosphodiesterase (PDE I)

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

其他說明

Jackson, E.K., et al. 1997. J. Cardiovasc. Pharmacol. 30, 798.
Ahn, H.S., et al. 1989. Biochem. Pharmacol.38, 3331.
Han, P., et al. 1989. J. Biol. Chem.274, 22337.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable