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Merck
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重要文件

440206

Sigma-Aldrich

LY 294002, 4′-NH2

A cell-permeable LY 294002 4′-amino derivative with enhanced potency against p110α/β/δ/γ.

同義詞:

LY 294002, 4′-NH2, 2-(4-Morpholinyl)-8-(4-aminophenyl)-4H-1-benzopyrone-4-one, PI-828

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About This Item

經驗公式(希爾表示法):
C19H18N2O3
CAS號碼:
分子量::
322.36
分類程式碼代碼:
12352200

品質等級

化驗

≥98% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

off-white

溶解度

DMSO: 30 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/C19H18N2O3/c20-14-6-4-13(5-7-14)15-2-1-3-16-17(22)12-18(24-19(15)16)21-8-10-23-11-9-21/h1-7,12H,8-11,20H2

InChI 密鑰

WUKMIBOGGXMBAC-UHFFFAOYSA-N

一般說明

A cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC50 in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4′-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Gharbi, S.I., et al., 2007. Biochem. J.404, 15.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Severine I Gharbi et al.
The Biochemical journal, 404(1), 15-21 (2007-02-17)
The PI3Ks (phosphatidylinositol 3-kinases) regulate cellular signalling networks that are involved in processes linked to the survival, growth, proliferation, metabolism and specialized differentiated functions of cells. The subversion of this network is common in cancer and has also been linked
Xiangcui Chen et al.
British journal of pharmacology, 176(12), 2079-2094 (2019-03-03)
Non-small-cell lung cancer (NSCLC) accounts for up to 80-85% of all lung cancers and has a disappointing prognosis. Flavonoids exert anticancer properties, mostly involving stimulation of ROS production without significant toxicity to normal cells. This study was aimed to delineate
Alain P Gobert et al.
Cell reports, 33(11), 108510-108510 (2020-12-17)
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine.

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