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Merck
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422682

Sigma-Aldrich

K ir1.1 Inhibitor, VU591

The Kir1.1 Inhibitor, VU591 controls the biological activity of Kir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.

同義詞:

K ir1.1 Inhibitor, VU591

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About This Item

經驗公式(希爾表示法):
C16H12N6O5
CAS號碼:
分子量::
368.30
分類程式碼代碼:
12352200

品質等級

化驗

≥98% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

light gray

溶解度

DMSO: 100 mg/mL, clear, dark brown

運輸包裝

ambient

儲存溫度

2-8°C

一般說明

A cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, Kir1.1 (IC50 = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over Kir6.2. In addition, it exhibits a modest off-target effect on the GABAA receptor (IC50 = 6.2 µM) among a panel of cardiac and central nervous system ion channels and receptors.
The Kir1.1 Inhibitor, VU591 controls the biological activity of Kir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.

包裝

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Bhave, G., et al. 2011. Mol Pharmacol.79, 42.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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