品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
light gray
溶解度
DMSO: 100 mg/mL, clear, dark brown
運輸包裝
ambient
儲存溫度
2-8°C
一般說明
A cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, Kir1.1 (IC50 = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over Kir6.2. In addition, it exhibits a modest off-target effect on the GABAA receptor (IC50 = 6.2 µM) among a panel of cardiac and central nervous system ion channels and receptors.
The Kir1.1 Inhibitor, VU591 controls the biological activity of Kir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.
包裝
Packaged under inert gas
警告
Toxicity: Regulatory Review (Z)
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他說明
Bhave, G., et al. 2011. Mol Pharmacol.79, 42.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
分析證明 (COA)
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