361558
GSK-3 Inhibitor XV - Calbiochem
The GSK-3 Inhibitor XV controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
同義詞:
GSK-3 Inhibitor XV - Calbiochem
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About This Item
經驗公式（希爾表示法）:
C25H14BrN3O6Ru
分子量：:
633.37
分類程式碼代碼:
12352200
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
purple
溶解度
DMSO: 6 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
一般說明
The racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3α GSK-3β, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3α GSK-3β, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage.
生化／生理作用
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他說明
Atilla-Gokcumen, G.E., et al. 2006. ChemBioChem7, 1443.
法律資訊
Sold for research purposes only, pursuant to an agreement with University of Pennsylvania.Sold under license of U.S. Patent 7,488,817.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
G Ekin Atilla-Gokcumen et al.
Chembiochem : a European journal of chemical biology, 7(9), 1443-1450 (2006-07-22)
A chiral second-generation organoruthenium half-sandwich compound is disclosed that shows a remarkable selectivity and cellular potency for the inhibition of glycogen synthase kinase 3 (GSK-3). The selectivity was evaluated against a panel of 57 protein kinases, in which no other
Rikke H Kofoed et al.
Neurobiology of disease, 136, 104720-104720 (2019-12-28)
Parkinson's disease (PD) is a currently incurable disease and the number of patients is expected to increase due to the extended human lifespan. α-Synuclein is a pathological hallmark of PD and variations and triplications of the gene encoding α-synuclein are
Xuzhe Zhang et al.
Molecular biology and evolution, 37(2), 507-523 (2019-10-22)
Evolution of highly invasive placentation in the stem lineage of eutherians and subsequent extension of pregnancy set eutherians apart from other mammals, that is, marsupials with short-lived placentas, and oviparous monotremes. Recent studies suggest that eutherian implantation evolved from marsupial
Lasse Reimer et al.
Brain pathology (Zurich, Switzerland), 31(1), 103-119 (2020-07-28)
Deposition of extensively hyperphosphorylated tau in specific brain cells is a clear pathological hallmark in Alzheimer's disease and a number of other neurodegenerative disorders, collectively termed the tauopathies. Furthermore, hyperphosphorylation of tau prevents it from fulfilling its physiological role as
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