238900

4-Cyano-3-methylisoquinoline

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM).

• 同義詞: 4-Cyano-3-methylisoquinoline, PKA Inhibitor XI
• 經驗公式（希爾表示法）: C₁₁H₈N₂
• CAS號碼: 161468-32-2
• 分子量：: 168.19
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white
• 溶解度: DMSO: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C11H8N2/c1-8-11(6-12)10-5-3-2-4-9(10)7-13-8/h2-5,7H,1H3
• InChI 密鑰: SZWLGBJCLZDZBY-UHFFFAOYSA-N

描述

一般說明

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.

A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).

生化／生理作用

Cell permeable: yes

Primary Target
PKA

Product competes with ATP.

Reversible: yes

Target IC₅₀: 30 nM against protein kinase A

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable