218832

Caspase-3/7 Inhibitor II

The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.

• 同義詞: Caspase-3/7 Inhibitor II, Ac-DNLD-CHO
• 經驗公式（希爾表示法）: C₂₀H₃₁N₅O₁₀
• CAS號碼: 775289-20-8
• 分子量：: 501.49
• MDL號碼: MFCD07368597
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: water: 1 mg/mL; DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: N([C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CC(=O)N
• InChI 密鑰: XZGUQURUQBIHMG-XUXIUFHCSA-N

描述

一般說明

A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC₅₀ = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC₅₀ = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.

Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 µM).

生化／生理作用

Cell permeable: no

Primary Target
caspase-3, caspase-7

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 3.2 nM and 22.6 nM, against caspases-3 and -7, respectively

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

Ac-Asp-Asn-Leu-Asp-CHO

分析報告

Single main spot with additional trace spot by TLC

其他說明

Yoshimori, A., et al. 2004. BMC Pharmacol.4, 7.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable