182540-M

Aromatase Inhibitor I

The Aromatase Inhibitor I, also referenced under CAS 331684-05-0, controls the biological activity of Aromatase.

• 同義詞: Aromatase Inhibitor I, 4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
• 經驗公式（希爾表示法）: C₁₇H₁₁N₃O₄
• CAS號碼: 331684-05-0
• 分子量：: 321.29
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 25 mg/mL
• 儲存溫度: −20°C

描述

一般說明

A potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC₅₀ = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.

A potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC₅₀ = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM).

生化／生理作用

Primary Target
P450 arom.

Target IC₅₀: 40 nM against P450arom

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Recanatini, M., et al. 2001. J. Med. Chem.44, 672.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable