14-917-M

CLK4 Protein, active, 10 µg

Active, N-terminal 6His-tagged, recombinant, human CLK4, amino acids 128-end, for use in Kinase Assays.

• 分類程式碼代碼: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

屬性

• 生物源: human
• 品質等級: 100; 300
• 重組細胞: expressed in baculovirus infected Sf21 cells
• 分子量: M_w 46 kDa
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable (kinase)
• NCBI登錄號: NM_020666
• UniProt登錄號: Q9HAZ1

描述

一般說明

CLK4 protein belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.

Product Source: N-terminal 6His-tagged, recombinant, human CLK4 amino acids 128-end expressed by baculovirus in Sf21 insect cells.

應用

Research Category
Signaling

生化／生理作用

Protein Target: CLK4

Target Sub-Family: CMGC

包裝

Also available in 250μg size as catalog # 14-917M and in bulk as catalog # 14-917-K.

品質

Routinely evaluated by phosphorylation of peptide YRRAAVPPSPSLSRHSSPHQS(p)EDEEE.

外觀

Purified using immobilized metal affinity chromatography.

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.

儲存和穩定性

6 months at -70°C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable