14-730-M
c-Kit (V560G) Protein, active, 10 µg
Active, N-terminal GST tagged recombinant human c-Kit, amino acids 544 -end, containing the V560G mutation, found in patients with gastrointestinal stromal tumours. For use in Kinase Assays.
同義詞:
Mast/stem cell growth factor receptor, SCFR, CD117
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About This Item
分類程式碼代碼:
12352202
eCl@ss:
32160405
NACRES:
NA.32
推薦產品
生物源
human
品質等級
100
300
分子量
Mw 76.6 kDa
製造商／商標名
Upstate®
技術
activity assay: suitable (kinase)
NCBI登錄號
UniProt登錄號
基因資訊
human ... KIT(3815)
一般說明
N-terminal GST tagged recombinant human c-Kit, amino acids 544 - end, containing the V560G mutation. The V560G mutation has been found in patients with gastrointestinal stromal tumours and has been linked to poor prognosis. This mutation confers increased susceptibility to Gleevec.
Product Source: Human c-Kit (V560G) expressed in Sf21 insect cells.
品質
Routinely evaluated by phosphorylation of 250μM GGMEDIYFEFMGGKKK.
外觀
Presented as a frozen solution in 50mM Tris/HCl pH 7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij 35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, and 0.1% 2-mercaptoethanol.
其他說明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant.
Frost, Michelle J, et al.
Molecular Cancer Therapeutics, 1, 1115-1124 (2002)
An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development.
Cullinane C, Dorow DS, Kansara M, Conus N, Binns D, Hicks RJ, Ashman LK, McArthur GA, Thomas DM.
Cancer Research, 65, 9633-9636 (2005)
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