124039

Akt Inhibitor X

InSolution, ≥97%

• 同義詞: InSolution Akt Inhibitor X, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl
• 經驗公式（希爾表示法）: C₂₀H₂₅ClN₂O · xHCl
• CAS號碼: 925681-41-0
• 分子量：: 344.88 (free base basis)
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• SMILES 字串: ClC(C=C1)=CC2=C1OC3=C(N2CCCCN(CC)CC)C=CC=C3
• InChI: 1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
• InChI 密鑰: SVKSJUIYYCQZEC-UHFFFAOYSA-N

描述

一般說明

A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 M), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2, the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound is also available.

生化／生理作用

Cell permeable: yes

Primary Target
Akt

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外觀

A 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O.

重構

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

其他說明

Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16982.
Thimmaiah, K.N., et al. 2005. J. Biol. Chem.280, 31924.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable