09-466

Anti-phospho-CrkL (Tyr207) Antibody

Upstate^®, from rabbit

• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse, rat, human
• 製造商／商標名: Upstate^®
• 技術: western blot: suitable
• NCBI登錄號: NP_005198
• UniProt登錄號: P46109
• 運輸包裝: dry ice
• 目標翻譯後修改: phosphorylation (pTyr207)
• 基因資訊: human ... CRKL(1399)

描述

一般說明

CRKL belongs to a family of adaptor proteins containing SH2/SH3 domains that couple to effector proteins including p130CAS, SOS, Abl, and Arg. CRKL plays a role in the mediation of Integrin- and Rac-dependent cell migration and in Ras-dependent activation of JNK. The protein is also involved in T-cell activation. Phosphorylation of CrkL on Tyr207 is known to be correlated with its inhibition.

特異性

Recognizes CrkL only when phosphorylated on Tyr207.

免疫原

KLH synthetic peptide including and encompassing Tyr 207 of human CrkL.

應用

Detect phospho-CrkL (Tyr207) using this Anti-phospho-CrkL (Tyr207) Antibody validated for use in WB.

Research Category
Signaling

Research Sub Category
Cytoskeletal Signaling

品質

Routinely evaluated by western blot on K563 cell lysates.

標靶描述

39 kDa

外觀

Purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析報告

Control
K562

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2