推薦產品
生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
human
製造商／商標名
Upstate®
技術
ChIP: suitable (ChIP-seq)
dot blot: suitable
inhibition assay: suitable (peptide)
multiplexing: suitable
western blot: suitable
同型
IgG
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
acetylation (Lys 4)
基因資訊
human ... H3F3B(3021)
特異性
组蛋白H3在Lys4上乙酰化时
预计具有广泛的物种交叉反应性
免疫原
KLH偶联合成肽包含序列 ...RT[AcK]Q...，其中[AcK]对应于人组蛋白H3的乙酰赖氨酸4
應用
建议的稀释度：
蛋白质印迹：1:1000 - 1:10,000
蛋白质印迹：1:1000 - 1:10,000
抗乙酰基组蛋白H3（Lys 4）抗体是一种兔多克隆抗体，用于检测乙酰基组蛋白H3（Lys 4），也称为H3K4Ac，组蛋白H3（乙酰基K4）& 已在Mplex、WB、PIA、ChIP、ChIP-seq、DB中得到验证。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
品質
已通过免疫印迹进行常规评估。
標靶描述
Mr ~17kDa
外觀
100 μL免疫亲和纯化的兔IgG，溶于在含有0.1 M Tris-甘氨酸（pH 7.4）和0.15 M NaCl，并含有0.05%叠氮化钠和30%甘油的缓冲液中
免疫亲和纯化
儲存和穩定性
自运送之日起在-20°C下保存1年
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Federico Forneris et al.
The Journal of biological chemistry, 281(46), 35289-35295 (2006-09-22)
Human lysine-specific demethylase (LSD1) is a chromatin-modifying enzyme that specifically removes methyl groups from mono- and dimethylated Lys4 of histone H3 (H3-K4). We used a combination of in vivo and in vitro experiments to characterize the substrate specificity and recognition
Runsheng He et al.
Nucleic acids research, 45(11), 6427-6441 (2017-04-13)
Epigenetic regulation of chromatin plays a critical role in controlling embryonic stem (ES) cell self-renewal and pluripotency. However, the roles of histone demethylases and activating histone modifications such as trimethylated histone 3 lysine 4 (H3K4me3) in transcriptional events such as
Cheng-Yu Yang et al.
Oncotarget, 8(20), 33756-33769 (2017-04-20)
Aberrant activation of histone lysine-specific demethylase (LSD1) increases tumorigenicity; hence, LSD1 is considered a therapeutic target for various human cancers. Although melatonin, an endogenously produced molecule, may defend against various cancers, the precise mechanism involved in its anti-oral cancer effect
Ya-Wei Chen et al.
Cancer, 119(24), 4259-4267 (2013-12-05)
Patterns of global histone modifications have been suggested to be predictors of clinical outcome in many cancers. However, the role of global histone modification patterns in oral squamous cell carcinoma (OSCC) is unclear. A retrospective clinicopathologic analysis was undertaken of
Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo.
Beconi, M; Aziz, O; Matthews, K; Moumne, L; O'Connell, C; Yates, D; Clifton, S; Pett et al.
Testing null
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