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重要文件

07-2114

Sigma-Aldrich

Anti-YAP1 Antibody

from rabbit, purified by affinity chromatography

同義詞:

Yorkie homolog, 65 kDa Yes-associated protein, YAP65

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702

生物源

rabbit

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

rat, human, mouse

技術

western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... YAP1(10413)

一般說明

YAP1 transcription factor is known to regulate the response to oxidative stress in S. cerevisiae. YAP1 is activated by increased levels of reactive oxygen species and moves quickly to the nucleus where it regulates the expression of up to 70 genes. Intramolecular disulphide bond formation is thought to be the mechanism of transcription factor control in YAP1. Tumor suppressor RASSF1A releases YAP1, which is then free to interact with p73 and transcription of pro-apoptotic puma begins. In the skin, YAP1 is the transcriptional effector of the Hippo signaling pathway and acts as the determinant of proliferative capacity of epidermal stem cells.

免疫原

GST-tagged recombinant protein corresponding to human YAP1.

應用

Research Category
Signaling
Research Sub Category
Oxidative Stress
This YAP1 antibody is validated for use in WB for the detection of the YAP1 protein.

品質

Evaluated by Western Blot in human liver tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected YAP1 on 10 µg of human liver tissue lysate.

標靶描述

~60 kDa observed

外觀

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human liver tissue lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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