06-680-AF555

Anti-Androgen Receptor Antibody, Alexa Fluor^™ 555 Conjugate

from rabbit, ALEXA FLUOR^™ 555

• 同義詞: Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.45

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: ALEXA FLUOR^™ 555
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: human, rat
• 物種活性（以同源性預測）: mouse (based on 100% sequence homology), canine (based on 100% sequence homology), horse (based on 100% sequence homology), bovine (based on 100% sequence homology)
• 技術: immunocytochemistry: suitable
• NCBI登錄號: NP_036634
• UniProt登錄號: P15207
• 目標翻譯後修改: unmodified
• 基因資訊: bovine ... Ar(280675) ; dog ... Ar(403588) ; human ... AR(367) ; mouse ... Ar(11835) ; rat ... Ar(24208)

描述

一般說明

Androgen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting in its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome.

免疫原

Epitope: N-terminal modulating region.

KLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor.

應用

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Hormones & Receptors

The unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications.

This Anti-Androgen Receptor Antibody, Alexa Fluor^™ 555 Conjugate is validated for use in Immunocytochemistry for the detection of Androgen Receptor.

品質

Evaluated by Immunocytochemistry in T47D cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected androgen receptor in T47D human breast cancer cells.

標靶描述

~110 kDa observed.

外觀

Affinity purified.

Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

法律資訊

ALEXA FLUOR is a trademark of Life Technologies

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable