05-23-0600

物质P

Neuropeptide found in high concentrations in the gut.

• 同義詞: 物质P
• 經驗公式（希爾表示法）: C₆₃H₉₈N₁₈O₁₃S
• CAS號碼: 33507-63-0
• 分子量：: 1347.63
• 分類程式碼代碼: 12352202
• NACRES: NA.51

屬性

• 品質等級: 100
• 化驗: ≥96% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: 5% acetic acid: 1 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
• InChI 密鑰: ADNPLDHMAVUMIW-CUZNLEPHSA-N

描述

一般說明

Substance P (SP) is an 11-amino acid neuropeptide belonging to the tachykinin (TAC) family of neuropeptides. It is encoded by the TAC1 gene in the central nervous system (CNS), the peripheral nervous system, and immune cells. Moreover, it serves essential functions in inflammation, angiogenesis, and wound healing. It is also found in high concentrations in the gut. When released from afferent nerves, it causes a neurogenic inflammatory response, including mast cell degranulation. It is known to induce Ca2+ mobilization and reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.

應用

Substance P (SP) has been used to enhance the lipid accumulation in 3T3‑L1 cells as they undergo differentiation into adipocytes in the presence of elevated glucose levels.

生化／生理作用

主靶标
物质P受体

产物不与ATP竞争。

可逆：否

细胞渗透性：否

包裝

是

警告

毒性：标准处理（A）

序列

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂

外觀

作为三氟乙酸盐提供。

重構

溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他說明

Roush, E.D., and Kwatra, M.M.1998.FEBS Lett.428, 291.
Chiwakata, C.B., et al. 1996.Infect.Immun.64, 5106.
Tanabe, T., et al. 1996.Eur. J. Pharmacol.299, 187.
Heath, M.J., et al. 1994.J. Neurophysiol.72, 1192.
Zhu, J., et al. 1994.Eur. J. Pharmacol.268, 279.
Garland, A.M., et al. 1993.Soc.Neurosci. 19, Abstract 104.6.
Wei, J.Y., et al. 1993.Soc.Neurosci. 19, Abstract 136.14.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable