Z-021

Ziprasidone hydrochloride solution

1 mg/mL ((as free base), Methanol:DMSO (80:20) (m/m)), certified reference material, ampule of 1 mL, Cerilliant^®

• 經驗公式（希爾表示法）: C₂₁H₂₁ClN₄OS · HCl
• CAS號碼: 122883-93-6
• 分子量：: 449.40
• MDL號碼: MFCD06795476
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: certified reference material
• 品質等級: 300
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 1 mg/mL ((as free base), Methanol:DMSO (80:20) (m/m))
• 格式: single component solution
• 儲存溫度: -10 to -25°C
• InChI: 1S/C21H21ClN4OS.ClH.H2O/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;;/h1-4,11,13H,5-10,12H2,(H,23,27);1H;1H2
• InChI 密鑰: ZCBZSCBNOOIHFP-UHFFFAOYSA-N

描述

一般說明

A Certified Spiking Solution^® applicable to use in forensic drug analysis or calibrator preparation by LC/MS or GC/MS. Ziprasidone is sold under the trade names Geodon and Zeldox for treatment of schizophrenia and bipolar disorder. Recent studies have suggested that Ziprasidone may increase the risk of Type II diabetes and hyperglycemia.

應用

• Enhanced Drug Delivery Systems: A study detailed the development of sustained-release ziprasiDonemicroparticles using Soluplus and ethyl cellulose. This formulation aims to eliminate the food effect and enhance bioavailability, marking a significant advancement in pharmaceutical formulations for schizophrenia treatment (Liu W et al., 2019).


• Targeted CNS Delivery:The study evaluated the brain-targeting and antipsychotic activities of nasally administered ziprasiDonethrough lipid-polymer hybrid nanocarriers. This novel delivery method could revolutionize treatment approaches in psychiatric medicine by enhancing drug efficacy and patient compliance in schizophrenia management (Abo El-Enin HA et al., 2023).


• Real-world Effectiveness in Bipolar Disorder:The study conducted a register-based national cohort study on the real-world effectiveness of pharmacological treatments for bipolar disorder, including ziprasidone. This research provides valuable insights into the therapeutic impacts and side effect profiles of ziprasiDonein a large patient population (Lahteenvuo M et al., 2023).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes,Central nervous system
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 71.6 °F
• 閃點（°C）: 22 °C