S-025

大麻素JWH-018标准液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 經驗公式（希爾表示法）: C₂₄H₂₃NO
• CAS號碼: 209414-07-3
• 分子量：: 341.45
• EC號碼: 200-659-6
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: certified reference material
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• drug control: Narcotic Licence Schedule D (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)
• 濃度: 100 μg/mL in methanol
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: forensics and toxicology; forensics and toxicology
• 格式: single component solution
• 儲存溫度: −20°C
• InChI: 1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3
• InChI 密鑰: JDNLPKCAXICMBW-UHFFFAOYSA-N

描述

一般說明

JWH-018是在几种版本的草药混合物“香料”中发现的合成大麻素。这种香料大麻素的非法使用集中在其精神活性作用上，该作用模仿了大麻中Δ⁹-THC的作用。尽管JWH-018比类似量的大麻有效得多，但对于通过典型的Δ⁹-THC检测方法进行检测也提出了重大挑战。
2009年7月，美国禁毒署（DEA）将JWH-018列入其关注的药物和化学物质清单。除了据报道在俄亥俄州和佛罗里达州缉获香料外，一些州还通过了立法行动，限制了JWH-018的销售或拥有，包括阿拉巴马州，阿肯色州，乔治亚州，堪萨斯州，肯塔基州，北达科他州和田纳西州。

應用

• Investigating Synthetic Cannabinoids in Leukemia: A study exploring the effects of synthetic cannabinoids like JWH-018 on leukemia and leukemic stem cells offers insights into potential therapeutic applications. This research highlights the value of JWH-018 as a tool for understanding cancer pathogenesis and developing new treatments, reinforcing its significance in biomedical research (Salcin et al., 2024).
  
  
  
  • Yeast Biosensor for Cannabinoid Detection: Research on a GPCR-based yeast biosensor for point-of-use cannabinoid determination, including synthetic cannabinoids such as JWH-018, showcases innovative biotechnological applications. This study demonstrates the biosensor′s utility in biomedical and environmental monitoring, potentially influencing drug safety and public health strategies (Miettinen et al., 2022).
  
  
  • Molecular Signaling of Synthetic Cannabinoids: A comparative study on the molecular signaling of synthetic cannabinoids, including JWH-018, provides critical data on their effects on CB1 and CB2 receptors. This research is pivotal for pharmacological studies aiming to understand the complex interactions of these compounds at the molecular level, thereby aiding in the development of targeted therapies for various conditions (Andersen et al., 2021).
  
  
  • Enhancing Drug Analysis Sensitivity: A study aimed at enhancing the nonfouling properties and sensitivity of Surface-Enhanced Raman Scattering (SERS) substrates for potent drug analysis, including JWH-018, highlights its application in forensic science. This research contributes to more accurate and rapid detection methods, essential for effective law enforcement and therapeutic monitoring (Masterson et al., 2021).
  
  
  
  

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup