C-165

肌酐-D₃ 溶液

100 μg/mL ((50:50) MeOH:Water), certified reference material, ampule of 1 mL, Cerilliant^®

• 經驗公式（希爾表示法）: C₄D₃H₄N₃O
• CAS號碼: 143827-20-7
• 分子量：: 116.14
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: certified reference material
• 品質等級: 300
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 100 μg/mL ((50:50) MeOH:Water)
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: pharmaceutical (small molecule)
• 格式: single component solution
• 儲存溫度: −20°C
• SMILES 字串: O=C1CN(C([2H])([2H])[2H])C(N1)=N
• InChI: 1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)/I1d3
• InChI 密鑰: DDRJAANPRJIHGJ-UEMYLDGTSA-N

描述

一般說明

在没有肾脏疾病的情况下，肌酐以相当恒定的速率排泄，通常用作尿生物标志物分析的基准。血清肌酐水平是肾功能的有用指标，并与糖尿病，心血管和循环系统疾病有关。该稳定标记的内标物适用于通过LC/MS或GC/MS定量肌酐水平，用于临床诊断，尿液药物测试或法医分析。

應用

• Quantification in biofluids: Creatinine-D₃ is crucial for the quantification of gut microbiota dysbiosis-related organic acids in human urine. This study demonstrates the utility of LC-MS/MS in assessing microbiome health and its impact on metabolic pathways, highlighting the compound′s role in biochemical research and clinical diagnostics (Lee et al., 2022).


• Urine creatinine measurement: The development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods for measuring creatinine in human urine showcase Creatinine-D₃ as a vital standard. This method is pivotal for ensuring accurate and reliable results in clinical and biochemical assays, particularly in kidney function testing (Fraselle et al., 2015).


• Enhanced detection techniques: Creatinine-D₃ is used in innovative analytical techniques like reactive-thermal desorption-extractive electrospray-ion mobility-tandem mass spectrometry. This method allows for the direct determination of urinary creatinine, providing faster, more sensitive analyses suitable for rapid clinical assessments (Devenport et al., 2014).


• Tracking creatine metabolism: In research exploring the metabolism of ingested creatine, Creatinine-D₃ is utilized to trace its metabolic fate in urine, plasma, and red blood cells. This application is crucial for studies on dietary supplements and their impact on health, particularly in sports science and nutrition (MacNeil et al., 2005).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H226,H301 + H311 + H331,H370
• 防範說明: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 3 - STOT SE 1
• 標靶器官: Eyes
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 75.2 °F
• 閃點（°C）: 24 °C