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Merck
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文件

790404P

Avanti

18:1 DGS-NTA(Ni)

Avanti Research™ - A Croda Brand

同義詞:

1,2-二-（9Z-十八烯酰基）-sn-甘油-3-[（N-（5-氨基-1-羧基戊基）亚氨基二乙酸）琥珀酰基]（镍盐）；狗NTA

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About This Item

經驗公式（希爾表示法）:
C53H93N2O15Ni
CAS號碼:
231615-77-3
分子量：:
1057.00
分類程式碼代碼:
12352211
NACRES:
NA.25

描述

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt)

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 10 mg (790404P-10mg)
pkg of 1 × 25 mg (790404P-25mg)
pkg of 1 × 5 mg (790404P-5mg)

製造商／商標名

Avanti Research™ - A Croda Brand

運輸包裝

dry ice

儲存溫度

−20°C

相關類別

一般說明

1,2-二油酰基-sn-甘油基-3-[（N-（5-氨基-1-羧基戊基）亚氨基二乙酸）琥珀酰基]氮川三乙酸（NTA）（18：1 DGS-NTA（Ni））是含镍的共轭磷脂 。NTA与镍离子中存在六个配位点中的四个螯合。

應用

1,2-二油酰基-sn-甘油基-3-[（N-（5-氨基-1-羧基戊基）亚氨基二乙酸）琥珀酰基]（镍盐）（18：1 DGS-NTA（Ni））用于：
  • 制备含卟啉-磷脂（PoP）偶联物的脂质体，用于蛋白质和肽的结合研究
  • 制备纳米级多层囊泡（NMV），用于抗原递送研究
  • 作为小单层囊泡（SUV）成分，用于制备平面脂质膜（PM）

生化／生理作用

1,2-二油酰基-sn-甘油基-3-[（N-（5-氨基-1-羧基戊基）亚氨基二乙酸）琥珀酰基]氮川三乙酸（NTA）（18：1 DGS-NTA（Ni））可用于结构生物学，尤其适合重组组氨酸标签结合蛋白。 虽然用处很大，但纳米颗粒在生物样品中存在稳定性问题。因此，NTA-脂质缀合物主要用作脂质体或纳米颗粒涂层。基于DGS-NTA（Ni）的纳米级多层囊泡（NMV）是有效的疫苗递送系统。

包裝

5 mL透明玻璃密封安瓿（790404P-25mg）

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

分析證明 (COA)

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The reconstitution of membrane-associated protein complexes poses significant experimental challenges. The core signaling complex in the bacterial chemotaxis system is an illustrative example: The soluble cytoplasmic signaling proteins CheW and CheA bind to heterogeneous clusters of transmembrane receptor proteins, resulting
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The Journal of biological chemistry, 285(46), 35428-35438 (2010-09-02)
VPS4 proteins are AAA(+) ATPases required to form multivesicular bodies, release viral particles, and complete cytokinesis. They act by disassembling ESCRT-III heteropolymers during or after their proposed function in membrane scission. Here we show that purified human VPS4A is essentially
Kelly A Dryden et al.
Protein science : a publication of the Protein Society, 18(12), 2629-2635 (2009-10-22)
Bacterial microcompartments (BMCs) are large intracellular bodies that serve as simple organelles in many bacteria. They are proteinaceous structures composed of key enzymes encapsulated by a polyhedral protein shell. In previous studies, the organization of these large shells has been
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The Journal of biological chemistry, 285(10), 7035-7044 (2009-12-22)
Her4 (ErbB-4) and Her2/neu (ErbB-2) are receptor-tyrosine kinases belonging to the epidermal growth factor receptor (EGFR) family. Crystal structures of EGFR and Her4 kinase domains demonstrate kinase dimerization and activation through an allosteric mechanism. The kinase domains form an asymmetric
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