推薦產品
![聚[(R)-3-羟基丁酸] natural origin](/deepweb/assets/sigmaaldrich/product/structures/129/476/7d1c924b-f644-4889-a2d6-d7a923ce382c/640/7d1c924b-f644-4889-a2d6-d7a923ce382c.png)
化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 1 mg (700070P-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand
脂質類型
bile acids
運輸包裝
dry ice
儲存溫度
−20°C
InChI
1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1
InChI 密鑰
CNWPIIOQKZNXBB-VCVMUKOKSA-N
一般說明
三羟基胆甾烷酸（THCA）是胆固醇的氧化代谢产物，是胆汁酸的前体。与内质网和过氧化物酶体相关的超长链酰基辅酶A合成酶（VLCS）可激活C27胆汁酸中间体THCA。
應用
三羟基胆甾烷酸已被用作一种甾醇，以测试其与人类mincle蛋白的反应性。
生化／生理作用
观察到三羟基胆甾烷酸（THCA）和二羟基胆甾烷酸（DHCA）在齐薇格综合征和胆汁淤积性肝病中均有积累。线粒体27羟化酶有利于合成DHCA和THCA的(25R)-异构体。
包裝
5 mL琥珀色玻璃螺旋盖样品瓶（700068P-1mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
No data available
閃點（°C）
No data available
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
S Ferdinandusse et al.
Journal of lipid research, 42(1), 137-141 (2001-02-13)
We identified a new peroxisomal disorder caused by a deficiency of the enzyme alpha-methylacyl-coenzyme A (CoA) racemase. Patients with this disorder show elevated plasma levels of pristanic acid and the bile acid intermediates di- and trihydroxycholestanoic acid (DHCA and THCA)
James O'Byrne et al.
The Journal of biological chemistry, 278(36), 34237-34244 (2003-06-18)
Bile acid-CoA:amino acid N-acyltransferase (BACAT) catalyzes the conjugation of bile acids to glycine and taurine for excretion into bile. By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in
Ryoko Kiyotake et al.
The Journal of biological chemistry, 290(42), 25322-25332 (2015-08-25)
C-type lectin receptors (CLRs) are an emerging family of pattern recognition receptors that recognizes pathogens or damaged tissue to trigger innate immune responses. However, endogenous ligands for CLRs are not fully understood. In this study, we sought to identify an
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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