QBD10199

dPEG^®₄-biotin acid

>95% (HPLC)

• 同義詞: Biotin-PEG-acid, Biotin-PEG₄-COOH, Biotin-PEG₄-acid, Carboxy-PEG₄-biotin, PEG₄-biotin acid
• 經驗公式（希爾表示法）: C₂₁H₃₇N₃O₈S
• 分子量：: 491.60
• 分類程式碼代碼: 12352106
• NACRES: NA.22

屬性

• 化驗: >95% (HPLC)
• 形狀: solid or viscous liquid
• 反應適用性: reaction type: Biotinylations; reaction type: Pegylations
• 聚合物結構: shape: linear; functionality: monofunctional
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

特點和優勢

dPEG₄ biotin acid consists of biotin and a propionic acid-functionalized tetraethylene glycol derivative. Numerous functional or reactive groups can modify the terminal acid moiety, including the acylating agents N-hydroxysuccinimide (NHS) and 2,3,5,6-tetrafluorophenol (TFP). Also, dPEG4 biotin acid reacts directly with primary amines using a suitable carbodiimide such as 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). The amphiphilic dPEG linker gives biotin excellent solubility in water and aqueous buffer, where biotin usually is poorly soluble. dPEG₄ biotin acid offers significantly superior solubility and performance characteristics compared to the traditional, highly hydrophobic biotinylation reagent known as LC-biotin. Moreover, although dPEG₄ biotin acid and LC-biotin have comparable linker lengths, dPEG₄ biotin acid will not trigger the aggregation and precipitation of conjugated biomolecules, even at high levels of biotin incorporation on the biomolecule. In contrast, LC-biotin triggers the aggregation and precipitation of biomolecules with the incorporation of a few LC-biotin groups onto the biomolecule.

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法律資訊

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable