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Merck
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重要文件

N8105

Sigma-Aldrich

3-哌啶甲酰胺

95%

同義詞:

3-Carbamoylpiperidine, 3-Piperidinecarboxamide

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About This Item

經驗公式(希爾表示法):
C6H12N2O
CAS號碼:
分子量::
128.17
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:

化驗

95%

形狀

solid

mp

103-106 °C (lit.)

SMILES 字串

NC(=O)C1CCCNC1

InChI

1S/C6H12N2O/c7-6(9)5-2-1-3-8-4-5/h5,8H,1-4H2,(H2,7,9)

InChI 密鑰

BVOCPVIXARZNQN-UHFFFAOYSA-N

應用

Reactant for synthesis of:
  • DPP-4 inhibitors
  • IKKβ inhibitors
  • Spiroimidazolidinone NPC1L1 inhibitors
  • Sulfamides
  • Phosphodiesterase 5 inhibtors
  • Anti-HIV agents

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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S Puglisi-Allegra et al.
Psychopharmacology, 70(3), 287-290 (1980-01-01)
An inhibitor of GABA-T (sodium n-dipropylacetate), a GABA agonist (muscimol hydrobromide) and an inhibitor of GABA uptake (R,S) nipecotic acid amide were administered to DBA/2 isolated aggressive mice throughout three successive daily experimental sessions. Aggressive responses, measured by an automated
Relationships between the chemical constitution of carbamoylpiperidines and related compounds, and their inhibition of ADP-induced human blood platelet aggregation.
R P Quintana et al.
Thrombosis research, 22(5-6), 665-680 (1981-06-01)
C Zhou et al.
Bioorganic & medicinal chemistry letters, 11(3), 415-417 (2001-02-24)
N-Substituted nipecotic and iso-nipecotic amides of beta-methylTrpLys tert-butyl ester were found to be novel, selective and potent agonists of the somatostatin subtype-2 receptor in vitro. For example iso-nipecotic amide 8a showed high hsst2 binding affinity (Ki = 0.5 nM) and
A Depaulis et al.
Psychopharmacology, 83(4), 367-372 (1984-01-01)
When GABA-potentiating compounds were administered IP to rats with prior experience of mouse-killing behaviour, a reduction of killing was observed with gamma-vinyl GABA (200 and 400 mg/kg) and nipecotic acid amide (400 mg/kg), while no significant effect was noted following

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