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Merck
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F3401

Supelco

2-氟苯胺

≥99%

同義詞:

1-氨基-2-氟苯

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About This Item

線性公式:
FC6H4NH2
CAS號碼:
分子量::
111.12
Beilstein:
1524219
EC號碼:
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.25

化驗

≥99%

折射率

n20/D 1.544 (lit.)

bp

182-183 °C (lit.)

mp

−29 °C (lit.)

密度

1.151 g/mL at 25 °C (lit.)

SMILES 字串

Nc1ccccc1F

InChI

1S/C6H6FN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2

InChI 密鑰

FTZQXOJYPFINKJ-UHFFFAOYSA-N

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生化/生理作用

由于人体暴露在制造中,异生素化合物 2-氟苯胺的代谢和排泄是重要的。发现它非常有效地代谢,主要是通过 4-羟基化,随后形成硫酸盐或葡糖苷酸。还观察到 N-乙酰化。至少 80% 的剂量在 24 小时内从尿液中排出。2-氟苯胺通过 4-羟基化和随后的对苯醌亚胺形成发挥其肾毒性作用。

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1C - STOT RE 2

標靶器官

Blood,hematopoietic system

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

140.0 °F - closed cup

閃點(°C)

60 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


分析證明 (COA)

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A L Sharma et al.
Applied biochemistry and biotechnology, 96(1-3), 155-165 (2002-01-11)
Poly(2-fluoroaniline) was prepared by both chemical and electrochemical polymerization in acidic medium. Characterization of poly(2-fluoroaniline) was accomplished experimentally using ultraviolet-visible, Fourier transform infrared, differential scanning calorimetry, thermal gravimetric analysis, and X-ray diffraction techniques, respectively. Scanning electron microscopy studies revealed globular
M Arivazhagan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 668-676 (2012-08-14)
The Fourier transform infrared (FT-IR) and Fourier transform Raman (FT-Raman) spectra of 4-chloro-2-fluoroaniline (CFA) have been recorded and analyzed. The equilibrium geometry, bonding features and harmonic vibrational frequencies have been investigated with the help of ab initio and density functional
M A Valentovic et al.
Toxicology, 75(2), 121-131 (1992-11-01)
Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with
Suria Jahan et al.
Transfusion, 60(4), 769-778 (2020-03-19)
Platelet engraftment following cord blood (CB) transplantation remains a significant hurdle to this day. The uncontrolled growth of ice, a process referred to as ice recrystallization, is one of several mechanisms that lead to cell loss and decreased potency during
J Vervoort et al.
NMR in biomedicine, 4(6), 255-261 (1991-12-01)
The present study describes results from an in vivo 19F NMR study on rats exposed to the xenobiotic compound 2-fluoroaniline. Qualitative pharmacokinetics and the biotransformation of 2-fluoroaniline were studied after exposure to 50 mg/kg body wt 2-fluoroaniline. Accumulation and elimination

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