934372
MC-Val-Cit-PAB-PNP
≥95%
同義詞:
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
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About This Item
經驗公式（希爾表示法）:
C35H43N7O11
CAS號碼:
分子量：:
737.76
Beilstein:
10322169
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.22
推薦產品
品質等級
化驗
≥95%
形狀
powder
儲存溫度
2-8°C
SMILES 字串
[N+](=O)([O-])c1ccc(cc1)OC(=O)OCc2ccc(cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)CCCNC(=O)N
InChI 密鑰
HYSPJPGXSALJRR-DHIFEGFHSA-N
應用
This is a bifunctional cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).
特點和優勢
The maleimide functionality can be used for bioconjugation to thiols in monoclonal antibodies while the activated carbonate esters can be used for construction of carbamate linkages with amine containing payloads.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
Qinhuai Lai et al.
European journal of medicinal chemistry, 199, 112364-112364 (2020-05-14)
Cryptophycin-52 (CR52), a tubulin inhibitor, exhibits promising antitumor activity in vitro (picomolar level) and in mouse xenograft models. However, the narrow therapeutic window in clinical trials limits its further development. Antibody-drug conjugate (ADC), formed by coupling cytotoxic compound (payload) to an
Zixuan Ye et al.
International journal of nanomedicine, 16, 2443-2459 (2021-04-06)
Specific modifications to carriers to achieve targeted delivery of chemotherapeutics into malignant tissues are a critical point for efficient diagnosis and therapy. In this case, bovine serum albumin (BSA) was conjugated with cetuximab-valine-citrulline (vc)-doxorubicin (DOX) to target epidermal growth factor
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