920568

tert-Butyl 3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoate

• 同義詞: Rigid linker for PROTAC^® development
• 經驗公式（希爾表示法）: C₁₃H₂₁N₃O₂
• 分子量：: 251.32
• 分類程式碼代碼: 12352106
• NACRES: NA.22

屬性

• 反應適用性: reagent type: linker
• 品質等級: 100
• 官能基: ester
• 儲存溫度: 2-8°C
• SMILES 字串: CC(C)(OC(CCC1=CN=C2CNCCN12)=O)C

描述

應用

tert-Butyl 3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoate is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920568
920657
ENAH38A2CCD6
AC5372910424

其他說明

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable