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Merck
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文件

861545

Sigma-Aldrich

N10-(三氟乙酰基)蝶酸

95%

同義詞:

4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl](2,2,2-trifluoroacetyl)amino]benzoic acid, N10-Trifluoroacetylpteroic acid

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About This Item

經驗公式(希爾表示法):
C16H11F3N6O4
CAS號碼:
分子量::
408.29
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

95%

形狀

solid

mp

270 °C (dec.) (lit.)

SMILES 字串

Nc1nc(O)c2nc(CN(c3ccc(cc3)C(O)=O)C(=O)C(F)(F)F)cnc2n1

InChI

1S/C16H11F3N6O4/c17-16(18,19)14(29)25(9-3-1-7(2-4-9)13(27)28)6-8-5-21-11-10(22-8)12(26)24-15(20)23-11/h1-5H,6H2,(H,27,28)(H3,20,21,23,24,26)

InChI 密鑰

IJGIHDXKYQLIMA-UHFFFAOYSA-N

應用

N10-(Trifluoroacetyl)pteroic acid is a structural component of folic acid. It can be used as a precursor to synthesize folic acid derivatives, γ-azido modified folic acid, and pteroyl-γ-glutamate-cysteine.

其他說明

残余 DMF

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry.
Huang B, et al.
Bioorganic & Medicinal Chemistry Letters, 22(9), 3152-3156 (2012)
Pteroyl-γ-glutamate-cysteine synthesis and its application in folate receptor-mediated cancer cell targeting using folate-tethered liposomes.
Zhang Y, et al.
Analytical Biochemistry, 332(1), 168-177 (2004)
Self?Assembly of Folic Acid Derivatives: Induction of Supramolecular Chirality by Hierarchical Chiral Structures.
Kamikawa Y, et al.
Chemistry?A European Journal , 10(23), 5942-5951 (2004)
Chun-Yen Ke et al.
Journal of the American Chemical Society, 127(20), 7421-7426 (2005-05-19)
The cell membrane folate receptor is a potential molecular target for tumor-selective drug delivery. To probe structural requirements for folate receptor targeting with low molecular weight radiometal chelates, specifically the role of the amino acid fragment of folic acid (pteroylglutamic

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