803618
DTME (dithio-bis-maleimidoethane)
同義詞:
1,1′-(dithiodi-2,1-ethanediyl)bis-1H-Pyrrole-2,5-dione, 1-[2-[[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]dithio]ethyl]-1H-pyrrole-2,5-dione, DTME
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About This Item
經驗公式（希爾表示法）:
C12H12N2S2O4
CAS號碼:
分子量：:
312.36
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.22
推薦產品
化驗
≥90%
形狀
powder
分子量
312.37
反應適用性
reagent type: cross-linking reagent
儲存條件
desiccated
溶解度
DMSO or DMF: soluble
運輸包裝
ambient
儲存溫度
2-8°C
SMILES 字串
O=C(C=CC1=O)N1CCSSCCN2C(C=CC2=O)=O
InChI
1S/C12H12N2O4S2/c15-9-1-2-10(16)13(9)5-7-19-20-8-6-14-11(17)3-4-12(14)18/h1-4H,5-8H2
InChI 密鑰
SGVWDRVQIYUSRA-UHFFFAOYSA-N
一般說明
DTME is a homobifunctional, maleimide crosslinker for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e., oligomerization) or protein interactions. DTME is similar in length to BMH but differs in containing a disulfide bond in its spacer arm, allowing crosslinks with DTME to be cleaved with reducing agent such as dithiothreitol (DTT).
特點和優勢
- Reactive groups: maleimide (both ends)
- Reactive towards: sulfhydryl groups
- Long (13.3A), cleavable, sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 11-atom disulfide spacer arm
- Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
- Cleavable by reduction of disulfide spacer arm with DTT, TCEP or other reducing agent
注意
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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