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Merck
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Key Documents

803596

Sigma-Aldrich

BM(PEG)3 (1,11-bismaleimido-triethyleneglycol)

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About This Item

經驗公式(希爾表示法):
C16H20N2O7
分子量::
352.34
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.22

化驗

≥90%

形狀

powder

分子量

352.34

反應適用性

reagent type: cross-linking reagent

儲存條件

desiccated

溶解度

water: soluble

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

O=C(C=CC1=O)N1CCOCCOCCOCCN2C(C=CC2=O)=O

InChI

1S/C16H20N2O7/c19-13-1-2-14(20)17(13)5-7-23-9-11-25-12-10-24-8-6-18-15(21)3-4-16(18)22/h1-4H,5-12H2

InChI 密鑰

OYRSKXCXEFLTEY-UHFFFAOYSA-N

一般說明

BM(PEG)2 and BM(PEG)3 are homobifunctional, maleimide crosslinkers for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e. oligomerization) or protein interactions. Because BM(PEG)2 and BM(PEG)3 have the same reactivity but differ in length, the relative success of these and similar reagents in forming crosslinks between sites in a protein oligomer or interaction can assist in determining intra- and intermolecular distances.

特點和優勢

  • Reactive groups: maleimide (both ends)
  • Reactive towards: sulfhydryl groups
  • Long, pegylated, sulfhydryl-to-sulfhydryl crosslinkers, composed of maleimide groups and 3-unit polyethylene glycol spacer arm
  • PEG spacers provide unique advantages, including enhanced solubility, increased stability, reduced tendency toward aggregation and reduced immunogenicity
  • Pure compounds with defined structure and molecular weight, ensuring reproducible protein-modification effects
  • Ideal for small molecule or peptide conjugations

注意

This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Ching-Jou Lim et al.
Pharmaceutical research, 21(11), 1985-1992 (2004-12-14)
To investigate if the cross-linking of transferrin receptor (TfR) induced by Tf-oligomers alters the endocytosis of receptor-ligand complexes in cultured tumor cells and hence increases intracellular drug release. An average of 3.5 Tf molecules per aggregate were cross-linked either by
Regina B Troyanovsky et al.
Molecular and cellular biology, 23(22), 7965-7972 (2003-10-31)
E-cadherin is a transmembrane protein that mediates Ca(2+)-dependent cell-cell adhesion. To study cadherin-cadherin interactions that may underlie the adhesive process, a recombinant E-cadherin lacking free sulfhydryl groups and its mutants with novel cysteines were expressed in epithelial A-431 cells. These
Beata Jastrzebska et al.
The Journal of biological chemistry, 279(52), 54663-54675 (2004-10-19)
Rhodopsin (Rho) is a G protein-coupled receptor that initiates phototransduction in rod photoreceptors. High expression levels of Rho in the disc membranes of rod outer segments and the propensity of Rho to form higher oligomeric structures are evident from atomic
Kyoko Takebe et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17(14), 2037-2047 (2003-11-05)
Epimorphin is a mesenchymal morphogen that has been shown to mediate epithelial-mesenchymal signaling interactions in various organs. We now show that epimorphin functions in hair follicle morphogenesis; using a novel ex vivo organ culture assay, we define a mechanism for

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