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Merck
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764736

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)-block-decane

PEG average Mn 2,000, PDLLA average Mn 2,000

同義詞:

PEG-PDLLA-decane, PEG-b-PLA-b-decane, PEG-PLA

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About This Item

分類程式碼代碼:
12162002
NACRES:
NA.23

形狀

pellets

分子量

PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)

降解時間

2-5 weeks

轉變溫度

Tm 29-33 °C

蛋白質二硫鍵異構酶

<1.1 (typical PEG)
<1.2
<1.3 (overall)

儲存溫度

2-8°C

相關類別

一般說明

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†

應用

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.

特點和優勢

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

>230.0 °F

閃點（°C）

> 110 °C

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Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing
Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to

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