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Merck
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文件

725765

Sigma-Aldrich

2-甲基-4-异噻唑啉-3-酮

95%

同義詞:

2-甲基-3(2H)-异噻唑啉酮

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About This Item

經驗公式(希爾表示法):
C4H5NOS
CAS號碼:
分子量::
115.15
Beilstein:
606203
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.21

化驗

≥94.0% (GC)
95%

形狀

lumps

雜質

≤5% water

SMILES 字串

CN1SC=CC1=O

InChI

1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3

InChI 密鑰

BEGLCMHJXHIJLR-UHFFFAOYSA-N

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應用

  • Insights into the mechanisms of within-species variation in sensitivity to chemicals: A case study using daphnids exposed to CMIT/MIT biocide.:研究水蚤对2-甲基-4-异噻唑啉-3-酮的不同种内敏感度,说明这些差异后潜藏的生化机制。该发现为环境安全性评估带来重要视点(Kim et al., 2023)。
  • Effects of the biocide methylisothiazolinone on Xenopus laevis wound healing and tail regeneration.:该研究评估2-甲基-4-异噻唑啉-3-酮对两栖动物再生过程的影响,有助了解它的生物作用和潜在毒性(Delos Santos et al., 2016)。
  • T cell lymphomatoid contact dermatitis: a challenging case and review of the literature.:该综述有讨论2-甲基-4-异噻唑啉-3-酮诱发的接触性皮炎,提供有关皮肤科应用和安全评估的宝贵信息(Knackstedt and Zug, 2015)。

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A

安全危害

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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Johannes Geier et al.
Contact dermatitis, 67(6), 334-341 (2012-09-22)
The frequency of sensitization to methylchloroisothiazolinone (MCI)/ methylisothiazolinone (MI) observed in the Information Network of Departments of Dermatology (IVDK) was constantly around 2.1% from 1998 to 2009. After that, it increased to 3.9% in 2011, paralleled by an increase in
Wolfgang Uter et al.
Contact dermatitis, 67(3), 125-129 (2012-05-09)
The preservative methylchloroisothiazolinone (MCI)/methylisothiazo- linone (MI) is an important allergen, and has thus been subject to regulation in some areas of exposure, mainly in cosmetics. To examine whether a decline in sensitization prevalence and intensity of elicitation (by the patch
Kevin H Gardner et al.
Archives of dermatology, 146(8), 886-890 (2010-06-23)
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), a common preservative in some brands of moist toilet paper (baby wipes and moist towelettes), has been reported to be a cause of allergic contact dermatitis. However, few cases have been reported in the United States. We report
Paula Maio et al.
Cutaneous and ocular toxicology, 31(2), 151-153 (2011-11-05)
Several preservatives are currently allowed in cosmetic products in the EU. However, only a few of them are strongly represented on the market: formaldehyde, parabens, formaldehyde releasers and methylchoroisothiazolinone/methylisothiazolinone (MCI/MI). MCI/MI has been widely used during recent years for the
Juan García-Gavín et al.
Contact dermatitis, 63(2), 96-101 (2010-07-16)
A few cases on primary sensitization by, and occupational contact dermatitis from, methylisothiazolinone in paints and glues have been published. In cosmetics, methylisothiazoline (MI) is permitted in a concentration of 100 p.p.m., while 15 p.p.m. for the mixture of methylchloroisothiazolinone

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