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Merck
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695467

Sigma-Aldrich

1,3,5-三氮杂-7-磷杂三环[3.3.1.13.7]癸烷

97%

同義詞:

1,3,5-三氮杂-7-磷代金刚烷, NSC 266642, PTA

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About This Item

經驗公式（希爾表示法）:
C6H12N3P
CAS號碼:
53597-69-6
分子量：:
157.15
MDL號碼:
MFCD00154905
分類程式碼代碼:
12352005
PubChem物質ID:
329761745
NACRES:
NA.22

化驗

97%

形狀

solid

反應適用性

reagent type: ligand
reaction type: Hydroformylations
reagent type: ligand
reaction type: Hydrogenations
reagent type: ligand
reaction type: Morita-Baylis-Hillman Reactions
reagent type: ligand
reaction type: Sonogashira Coupling
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling

mp

244-250 °C

官能基

phosphine

SMILES 字串

C1N2CN3CN1CP(C2)C3

InChI

1S/C6H12N3P/c1-7-2-9-3-8(1)5-10(4-7)6-9/h1-6H2

InChI 密鑰

FXXRPTKTLVHPAR-UHFFFAOYSA-N

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相關類別

一般說明

在空气中稳定的有机催化剂，可用于 Baylis-Hillman 转化

應用

  • The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics.：该研究通过差异凝胶电泳(DIGE)蛋白质组学研究钌化合物的抗转移作用。分析了钌络合物中的1,3,5-三氮杂-7-磷杂金刚烷及其生物作用，说明它的潜在抗癌性(Guidi et al., 2013)。
  • Synthesis, antimicrobial and antiproliferative activity of novel silver(I) tris(pyrazolyl)methanesulfonate and 1,3,5-triaza-7-phosphadamantane complexes.：该研究详述含有1,3,5-三氮杂-7-磷杂金刚烷的新型银络合物的合成，评估它们的抗菌和抗增殖活性，说明该化合物可用于生物医学领域(Pettinari et al., 2011)。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Phillips, A. D.; Gonsalvi, L. et al.
Coordination Chemistry Reviews, 248, 955-955 (2004)
William D J Tremlett et al.
Journal of inorganic biochemistry, 199, 110768-110768 (2019-07-30)
Organometallic compounds based on bioactive ligand systems have shown promising antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives as bioactive ligands resulted in organometallic complexes with potent anticancer activity, but they lack aqueous solubility for further development. We report
He, Z. et al
Advanced Synthesis & Catalysis, 368, 413-413 (2006)
Leila Tabrizi et al.
Dalton transactions (Cambridge, England : 2003), 48(2), 728-740 (2018-12-19)
The new cyclometalated ruthenium(ii) complex, [Ru(CCC-Nap)(Ibu)(PTA)] was designed and synthesized using ibuprofen (Ibu), 1,3,5-triaza-7-phosphaadamantane (PTA) and CCC-pincer containing naproxen moiety (CCC-Nap) as ligands. The compounds were fully characterized by elemental analysis, FT-IR, multinuclear (1H, 13C, and 31P) NMR spectroscopy, and
Sabina W Jaros et al.
Molecules (Basel, Switzerland), 25(9) (2020-05-07)
The present study reports the synthesis, characterization, and crystal structure of a novel bioactive metal-organic framework, [Ag4(µ-PTA)2(µ3-PTA)2(µ4-pma)(H2O)2]n·6nH2O (bioMOF 1), which was assembled from silver(I) oxide, 1,3,5-triaza-7-phosphaadamantane (PTA), and pyromellitic acid (H4pma). This product was isolated as a stable microcrystalline solid
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文章

Trialkylphosphine for MBH Reactions

Amines and phosphines in nucleophilic catalysis are discussed, addressing the air sensitivity of phosphines.

相關內容

Frost Group – Professor Product Portal

The Frost group has a longstanding interest in aqueous phase organometallic chemistry with an emphasis on water-soluble phosphine ligands. One focus of this research group has been centered on the chemistry of the neutral, air stable, and water-soluble heterocyclic phosphine 1,3,5-Triaza-7-phosphaadamantane (PTA). PTA is a small phosphine ligands with a cone angle of ~103°. PTA binds metal centers quite strongly and is electronically more donating than PPh3. Ruthenium complexes of PTA have exhibited impressive anticancer activity. A wide variety of transition metal complexes of PTA have been utilized as catalysts for reactions such as hydrogenation, C-C bond forming reactions, atom transfer radical addition, and nitrile hydration.

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