推薦產品
化驗
96%
折射率
n20/D 1.56 (lit.)
bp
199-200 °C (lit.)
密度
1.549 g/mL at 25 °C (lit.)
SMILES 字串
Cc1ccncc1Br
InChI
1S/C6H6BrN/c1-5-2-3-8-4-6(5)7/h2-4H,1H3
InChI 密鑰
GSQZOLXWFQQJHJ-UHFFFAOYSA-N
應用
3-Bromo-4-methylpyridine may be used as a building block in the preparation of:
- substituted 4-(2,2-diphenylethyl)pyridine-N-oxides for use as potent phosphodiesterase type 4 (PDE4) inhibitors
- benzodiazepine site ligands bearing tricyclic pyridone moiety for human GABAA receptor
- a novel isomer of ascididemin
- 3-bromopyridine-4-carbonitrile
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
174.9 °F - closed cup
閃點（°C）
79.4 °C - closed cup
個人防護裝備
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
James Crawforth et al.
Bioorganic & medicinal chemistry letters, 14(7), 1679-1682 (2004-03-18)
A series of tricyclic pyridones has been evaluated as benzodiazepine site ligands with functional selectivity for the alpha(3) over the alpha(1) containing subtype of the human GABA(A) receptor ion channel. This investigation led to the identification of a high affinity
Richard Frenette et al.
Bioorganic & medicinal chemistry letters, 12(20), 3009-3013 (2002-09-25)
A detailed SAR study directed toward the optimization of pharmacokinetic parameters for analogues of L-791,943 is reported. The introduction of a soft metabolic site on this structure permitted the identification of L-826,141 as a potent phosphodiesterase type 4 (PDE4) inhibitor
Condensed heteroaromatic ring systems. XV. Synthesis of pyranopyridinones from halopyridinecarbonitriles.
Sakamoto T, et al.
Chemical & Pharmaceutical Bulletin, 36(5), 1890-1894 (1988)
Ida Nymann Petersen et al.
Chemical communications (Cambridge, England), 48(72), 9092-9094 (2012-08-07)
A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended
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