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Merck
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文件

480894

Sigma-Aldrich

O-(四氢-2H-吡喃-2-基)羟基胺

96%

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About This Item

經驗公式(希爾表示法):
C5H11NO2
CAS號碼:
分子量::
117.15
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

96%

bp

81 °C/20 mmHg (lit.)

mp

34-37 °C (lit.)

SMILES 字串

NOC1CCCCO1

InChI

1S/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2

InChI 密鑰

NLXXVSKHVGDQAT-UHFFFAOYSA-N

一般說明

O-(四氢-2H-吡喃-2-基)羟基胺(OTX)是一种O-取代的羟胺。据报道,OTX与碱性凝胶电泳结合,可改善检测DNA中单链断裂(SSB)的过程。

應用

O-(四氢-2H-吡喃-2-基)羟基胺可用于合成2-(5-溴噻吩-2-磺酰胺基)-N-(四氢-2H-吡喃-2-基氧基)乙酰胺。
它可用于合成以下潜在的组蛋白脱乙酰酶(HDAC)抑制剂:
  • 2-[1-(萘-2-磺酰基)-杂环基]-嘧啶-5-羧酸(四氢吡喃-2-基氧基)-酰胺
  • (E)-3-(2-苄基-1-氧代异吲哚-6-基)-N-(四氢-2H-吡喃-2-基氧基)丙烯酰胺
  • 3-(1-苯磺酰基-2,3-二氢-1H-吲哚-5-基)-N-羟基丙烯酰胺

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

179.6 °F - closed cup

閃點(°C)

82 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Tetrahedron Letters, 45, 133-133 (2004)
Elisa Nuti et al.
European journal of medicinal chemistry, 46(7), 2617-2629 (2011-04-26)
Matrix metalloproteinases (MMPs) are important factors in gliomas since these enzymes facilitate invasion into the surrounding brain and participate in neovascularization. In particular, the gelatinases (MMP-2 and MMP-9), and more recently MMP-25, have been shown to be highly expressed in
Patrick Angibaud et al.
European journal of medicinal chemistry, 40(6), 597-606 (2005-06-01)
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.
Chihiro Shinji et al.
Bioorganic & medicinal chemistry, 14(22), 7625-7651 (2006-08-01)
A series of hydroxamic acid derivatives bearing a cyclic amide/imide group as a linker and/or cap structure, prepared during our structural development studies based on thalidomide, showed class-selective potent histone deacetylase (HDAC)-inhibitory activity. Structure-activity relationship studies indicated that the steric
Han-Li Huang et al.
PloS one, 7(8), e43645-e43645 (2012-08-29)
Recently, histone deacetylase (HDAC) inhibitors have emerged as a promising class of drugs for treatment of cancers, especially subcutaneous T-cell lymphoma. In this study, we demonstrated that MPT0E028, a novel N-hydroxyacrylamide-derived HDAC inhibitor, inhibited human colorectal cancer HCT116 cell growth

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