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Merck
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重要文件

219177

Sigma-Aldrich

4,5-二甲基噻唑

97%

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About This Item

經驗公式(希爾表示法):
C5H7NS
CAS號碼:
分子量::
113.18
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

97%

形狀

powder

折射率

n20/D 1.521 (lit.)

bp

158 °C/742 mmHg (lit.)

密度

1.07 g/mL at 25 °C (lit.)

SMILES 字串

Cc1ncsc1C

InChI

1S/C5H7NS/c1-4-5(2)7-3-6-4/h3H,1-2H3

InChI 密鑰

UWSONZCNXUSTKW-UHFFFAOYSA-N

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一般說明

Radical bromination of 4,5-dimethylthiazole using N-bromosuccinimide in the presence of 2,2′-azobisisobutyronitrile yields mono-, tri- and tetrabromo compounds.

應用

4,5-Dimethylthiazole was used in the preparation of 4-(bromomethyl)-5-(dibromomethyl)thiazole.

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

123.8 °F - closed cup

閃點(°C)

51 °C - closed cup


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Mouaffak Al Hariri et al.
The Journal of organic chemistry, 62(2), 405-410 (1997-01-24)
4-(Bromomethyl)-5-(dibromomethyl)thiazole (1) was prepared in good yields by bromination of 4,5-dimethylthiazole with 3.3 equiv of NBS in the presence of AIBN. Treatment of 1 with sodium iodide led to a thiazole o-quinodimethane 2 which was trapped in situ with dienophiles
Selective Bromination of 4, 5-Dimethylthiazole with N-Bromosuccinimide.
Al Hariri M, et al.
European Journal of Organic Chemistry, 1998(4), 593-594 (1998)
Le Wu et al.
Journal of molecular neuroscience : MN, 56(4), 848-857 (2015-02-24)
Lipoxin A4 (LXA4), a potent antioxidant and anti-inflammation mediator, protects brains against cerebral ischemia/reperfusion (I/R) injury in vivo. However, few reports concern its function on astrocytes during cerebral I/R injury. The pathogenesis of cerebral I/R injury involves oxidative stress caused
João G Marques et al.
Pharmaceutical research, 31(9), 2516-2528 (2014-03-14)
Cancer multi-drug resistance is a major issue associated with current anti-tumoral therapeutics. In this work, Crizotinib an anti-tumoral drug approved for the treatment of non-small lung cancer in humans, and Sildenafil (Viagra(®)), were loaded into micellar carriers to evaluate the
Szu-Jung Chen et al.
Inflammation, 38(2), 534-545 (2014-07-06)
Eicosatrienoic acid (Δ11,14,17-20:3; ETrA) is a rare naturally occurring n-3 polyunsaturated fatty acid (PUFA). Using murine RAW264.7 cells, the objectives were to determine how ETrA modulated phospholipid fatty acid compositions and the production of pro-inflammatory mediators. Incubation cells with ETrA

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