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Merck
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Key Documents

145998

Sigma-Aldrich

2-喹喔啉甲酰氯

同義詞:

2-Quinoxalinecarbonyl chloride

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About This Item

經驗公式(希爾表示法):
C9H5ClN2O
CAS號碼:
分子量::
192.60
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

mp

113-115 °C (lit.)

官能基

acyl chloride

儲存溫度

2-8°C

SMILES 字串

ClC(=O)c1cnc2ccccc2n1

InChI

1S/C9H5ClN2O/c10-9(13)8-5-11-6-3-1-2-4-7(6)12-8/h1-5H

InChI 密鑰

SOPDQKNXOCUBSR-UHFFFAOYSA-N

一般說明

2-Quinoxaloyl chloride reacts with chiral α-hydroxy carboxylic acids to yield UV and fluorescent derivatives.

應用

2-Quinoxaloyl chloride was used in the synthesis of novel DNA interactive quinoxaline-carbohydrate hybrids possessing disaccharides as the carbohydrate moieties.
Reactant involved in the synthesis of a variety of inhibitors including:
  • Gelatinase inhibitors for cancer treatments
  • mGluR5 non-competitve antagonists
  • Heterocyclic analogs used as SIRT1 activators
  • 3rd Generation multidrug resistance modulators

Reactant involved in preparation of PET ligants for breast cancer resistance protein imaging

象形圖

Corrosion

訊號詞

Danger

危險聲明

危險分類

Eye Dam. 1 - Skin Corr. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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分析證明 (COA)

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HPLC resolution of hydroxyl carboxylic acid enantiomers using 2-quinoxaloyl chloride as a new precolumn derivatizing agent.
Brightwell M, et al.
Journal of Liquid Chromatography and Related Technologies, 18(14), 2765-2781 (1995)
Kazunobu Toshima et al.
Bioorganic & medicinal chemistry letters, 14(11), 2777-2779 (2004-05-06)
The novel DNA interactive quinoxaline-carbohydrate hybrids possessing disaccharides as the carbohydrate moieties were designed and synthesized, and their DNA photocleaving abilities were evaluated in order to examine the effect of the disaccharide structures. The configurations of the glycosidic bonds in

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