134155

1-甲基吲哚-2-甲酸

98%

• 同義詞: NSC 68357
• 經驗公式（希爾表示法）: C₁₀H₉NO₂
• CAS號碼: 16136-58-6
• 分子量：: 175.18
• MDL號碼: MFCD00005801
• 分類程式碼代碼: 12352100
• PubChem物質ID: 24848134
• NACRES: NA.22

屬性

• 化驗: 98%
• 形狀: powder
• mp: 212-213 °C (dec.) (lit.)
• SMILES 字串: Cn1c(cc2ccccc12)C(O)=O
• InChI: 1S/C10H9NO2/c1-11-8-5-3-2-4-7(8)6-9(11)10(12)13/h2-6H,1H3,(H,12,13)
• InChI 密鑰: MAHAMBLNIDMREX-UHFFFAOYSA-N

描述

一般說明

1-Methylindole-2-carboxylic acid reacts with thionyl chloride to yield sulfinyl chlorides.

應用

• Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors
• Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions
• Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes
• Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation
• Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis
• Reactant for preparation of anthranilic acid mimics as bacterial translation inhibitors

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H315,H319,H335
• 防範說明: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves