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化驗
98%
形狀
powder
mp
131-134 °C (lit.)
溶解度
acetone: soluble 25 mg/mL, clear, colorless to light yellow
SMILES 字串
CC(=O)CC(=O)Nc1ccc(Cl)cc1
InChI
1S/C10H10ClNO2/c1-7(13)6-10(14)12-9-4-2-8(11)3-5-9/h2-5H,6H2,1H3,(H,12,14)
InChI 密鑰
JMRJWEJJUKUBEA-UHFFFAOYSA-N
一般說明
4′-Chloroacetoacetanilide was trilithiated with lithium diisopropylamide and condensed with several aromatic esters, followed by neutralization, separate acid cyclization and rearrangements to yield 4-anilino-6-aryl-2H-pyran-2-ones. It undergoes three-component reaction with a mixture of aromatic aldehyde and 5-aminotetrazole to form N,7-diaryl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide.
應用
4′-Chloroacetoacetanilide was used in recombinant androgen receptor competitive binding assay for analysis of natural, synthetic and environmental chemicals.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Synthesis and antimicrobial activity of n, 7-diaryl-5-methyl-4, 7-dihydrotetrazolo [1, 5-a] pyrimidine-6-arboxamides.
Gein VL, et al.
Pharmaceutical Chemistry Journal, 44(7), 366-369 (2010)
Preparation of 4-anilino-6-aryl-2 H-pyran-2-ones from trilithiated acetoacetanilides and aromatic esters.
Downs JR, et al.
Canadian Journal of Chemistry, 82(5), 659-664 (2004)
Hong Fang et al.
Chemical research in toxicology, 16(10), 1338-1358 (2003-10-21)
A number of environmental and industrial chemicals are reported to possess androgenic or antiandrogenic activities. These androgenic endocrine disrupting chemicals may disrupt the endocrine system of humans and wildlife by mimicking or antagonizing the functions of natural hormones. The present
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