F3379

纤维蛋白肽 B 人

≥97% (HPLC)

• 經驗公式（希爾表示法）: C₆₆H₉₃N₁₉O₂₅
• CAS號碼: 36204-23-6
• 分子量：: 1552.56
• MDL號碼: MFCD00076439
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24894841

屬性

• 生物源: human
• 化驗: ≥97% (HPLC)
• 形狀: powder
• UniProt登錄號: P02675
• 儲存溫度: −20°C
• SMILES 字串: CC(C)C(NC(=O)CNC(=O)C1CCC(=O)N1)C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NC(Cc2ccccc2)C(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(O)=O
• InChI: 1S/C66H93N19O25/c1-31(2)53(85-49(91)29-73-55(99)35-16-19-47(89)75-35)64(108)83-42(26-46(68)88)61(105)82-43(27-52(96)97)62(106)81-41(25-45(67)87)60(104)78-37(18-21-51(94)95)57(101)77-36(17-20-50(92)93)56(100)72-28-48(90)76-39(23-33-11-6-4-7-12-33)58(102)80-40(24-34-13-8-5-9-14-34)59(103)84-44(30-86)63(107)74-32(3)54(98)79-38(65(109)110)15-10-22-71-66(69)70/h4-9,11-14,31-32,35-44,53,86H,10,15-30H2,1-3H3,(H2,67,87)(H2,68,88)(H,72,100)(H,73,99)(H,74,107)(H,75,89)(H,76,90)(H,77,101)(H,78,104)(H,79,98)(H,80,102)(H,81,106)(H,82,105)(H,83,108)(H,84,103)(H,85,91)(H,92,93)(H,94,95)(H,96,97)(H,109,110)(H4,69,70,71)
• InChI 密鑰: MYRIFIVQGRMHRF-UHFFFAOYSA-N
• 基因資訊: human ... FGB(2244)

描述

Amino Acid Sequence

Glp-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg

一般說明

Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer. It is cleaved off from the N-terminal of the fibrinogen β chain. This peptide is composed of 14 amino acids.

生化／生理作用

凝血酶对纤维蛋白原作用而连续释放纤维蛋白肽对正常的纤维蛋白聚合至关重要。从纤维蛋白原 Bβ 链上切下纤维蛋白肽 B 可暴露 E 域聚合位点 E(B)，该位点可与血小板、成纤维细胞和内皮细胞相互作用。

Cleavage of fibrinopeptide B from fibrinogen Bβ chains exposes E domain polymerization sites, E(B), that interact with platelets, fibroblasts and endothelial cells.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)