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• Seed Train Intensification Using High Cell Density Cryopreservation

  This article explains the benefits of high cell density cryopreservation (HCDC) and how to implement it.

• Impact of DMSO And Freezing Technique in Developing a High Cell Density Cryopreservation Process for Upstream Bioprocessing

  Here, we evaluated how dimethyl sulfoxide and freezing techniques impact viable cell density and titer production in an HCDC intensified seed train.

• Optimizing CHO Cells for Higher Productivity

  This application note describes the benefits and performance of  Cellvento^® 4CHO-X Expansion Medium designed for multiple cell expansion steps from vial thaw to N-1 stages to generate higher biomass for inoculating fed-batch production bioreactors.

• Cell Retention Technology and Specialized Cell Culture Media for Intensified Upstream Processing

  This study demonstrates the use of a Cellicon^® filter and controller in an N-1 perfusion process with Cellvento^® 4CHO-X expansion medium as compared to a control seed train using shake flasks.

• Reproducible Scaling of a Cell Retention Filter Using the Cellicon^® Cell Retention Solution

  This page describes the design attributes of the Cellicon^® Filter Assembly and how they simplify process scale-up.

• Operational and Financial Advantages of Cellicon^{® Cell Retention Solution in an N-1 Perfusion Process}

  The following study compares an N-1 perfusion process at the 2,000 L scale using our Cellicon^® Cell Retention Solution versus a commercially available cell retention device.