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Merck

BRCA2

breast cancer 2, early onset

同義詞:
BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
物種:
Human BRCA2 (675), Mouse Brca2 (12190), Rat Brca2 (360254), domestic guinea pig Brca2 (100713136), Zebrafish brca2 (566758), naked mole-rat Brca2 (101698015), chicken BRCA2 (374139), sheep BRCA2 (101109980), fruit fly Brca2 (37916), cow BRCA2 (507069) ...更多
UniProtKB ID:
P51587, O00183, O15008, Q13879, Q5TBJ7
基因 ID:
  • Human(675) Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
  • Mouse(12190) breast cancer 2
  • Rat(360254) breast cancer 2, early onset
  • domestic guinea pig(100713136) breast cancer 2, early onset
  • Zebrafish(566758) breast cancer 2, early onset
  • naked mole-rat(101698015) breast cancer 2, early onset
  • chicken(374139) breast cancer 2, early onset
  • sheep(101109980) breast cancer 2, early onset
  • fruit fly(37916) Breast cancer 2, early onset homolog
  • cow(507069) breast cancer 2, early onset
  • dog(474180) breast cancer 2, early onset
  • domestic cat(493878) breast cancer 2, early onset
  • Horse(100064578) breast cancer 2, early onset

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Antibodies

產品編號
描述
物種活性
應用
OP95
抗-BRCA2 (Ab-1) 小鼠mAb (2B), liquid, clone 2B, Calbiochem®,
物種活性
human
應用
HPA026815
抗-BRCA2 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物種活性
human
應用
immunofluorescence
AB9986
抗磷酸化BRCA2（Ser3291）抗体, from rabbit, purified by affinity chromatography,
物種活性
canine, cat, chimpanzee, equine, hamster, horse, human, mouse, rat, rhesus macaque, rhesus monkey
應用
dot blot
immunocytochemistry
immunohistochemistry
05-666
抗BRCA2抗体，克隆5.23, clone 5.23, Upstate®, from mouse,
物種活性
human
應用
immunocytochemistry
western blot
SAB4502860
Anti-BRCA2 antibody produced in rabbit, affinity isolated antibody,
物種活性
human, rat
應用
ELISA
immunohistochemistry