SMB00915
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester)
≥95% (HPLC)
Synonym(s):
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester), (3α,5β,12β)-3,12-dihydroxy-11-oxo-cholan-24-oic-acid methyl ester
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About This Item
Empirical Formula (Hill Notation):
C25H40O5
CAS Number:
Molecular Weight:
420.58
UNSPSC Code:
41141802
NACRES:
NA.25
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
powder
color
white to beige
mp
153.5—154.5 °C
solubility
chloroform: 20 mg/mL, colorless to light yellow
storage temp.
2-8°C
General description
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) is a more potent analog of microbiome metabolite BAA485 (12-oxolithocholic acid) that activates the Pyrin inflammasome in myeloid and intestinal epithelial cells. BAA473 potently induces secretion of IL1β and IL18 in LPS-primed PBMCs and THP-1 cells.
Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance.
Application
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) finds application in metabolomics, biochemical and microbiome research.
Features and Benefits
- Can be used in Metabolomics and Biochemical research
- High-quality compound suitable for multiple research applications
Other Notes
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Irina Alimov et al.
The Journal of biological chemistry, 294(10), 3359-3366 (2019-01-17)
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota. The conversion of bile acids by the gut microbiome is now recognized as a factor affecting both host
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