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SAB4502369

Sigma-Aldrich

Anti-HDAC8 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

FKSG78, G-protein coupled receptor 95, GPR87, GPR95, Probable G-protein coupled receptor 87

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About This Item

MDL number:
MFCD02686596
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 41 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q9BY41

UniProt accession no.

Q9BY41

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HDAC8(55869)

General description

Anti-HDAC8 Antibody detects endogenous levels of total HDAC8 protein.
The HDAC8 (histone deacetylase 8) gene is mapped to human chromosome Xq13.1. The encoded protein belongs to the class 1 histone deacetylase family.

Immunogen

The antiserum was produced against synthesized peptide derived from human HDAC8.

Immunogen Range: 5-54

Biochem/physiol Actions

The HDAC8 (histone deacetylase 8) protein is significantly involved in cartilage development and matrix-specific gene transcription by catalyzing histone acetylation. HDAC8 has Zn2+-dependent hydrolase activity that deacetylates the acetyl lysine residues of both histone and non-histone proteins. Deacetylation of structural maintenance of chromosome protein 3(SMC3) by HDAC8 is necessary for recycling of cohesin complex during cell cycle. Mutation in the gene is observed in Cornelia de Lange syndrome which is characterised by mental retardation and facial deformity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cloning and characterization of human histone deacetylase 8.
Van den Wyngaert I
Febs Letters, 478(1-2), 77-83 (2000)
Structure-Based Identification of HDAC8 Non-histone Substrates.
Alam N
Structure, 24(3), 458-468 (2016)
Bo Du et al.
The Kaohsiung journal of medical sciences, 36(11), 904-910 (2020-07-10)
Alcoholic hepatitis (AH) is identified as an inflammatory syndrome with high morbidity and mortality as a result of severe hepatocellular dysfunction and liver injury. Accumulated studies indicated that miRNAs are involved in AH. The potential effect of miR-451a in AH
MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.
Chen W
Biochimica et Biophysica Acta, 1863(12), 2881-2891 (2016)
Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders.
Deardorff MA
Protein Science, 25(11), 1965-1976 (2016)

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