SAB1307254
ANTI-BAT1(C-TERMINAL) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
56 kDa U2AF65-associated protein, BAT1, DDX39B, Spliceosome RNA helicase DDX39B, UAP56
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
48991 Da
species reactivity
human
technique(s)
flow cytometry: 1:10-1:50
immunohistochemistry: 1:10-1:50
western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DDX39B(7919)
Related Categories
General description
BAT1, also known as UAP56 or DExD-box helicase 39B (DDX39B), is encoded in the central region of the major histocompatibility complex (MHC) on the short arm of human chromosome 6p21.33. It is a member of DEAD box family of RNA-binding proteins and is characterized with the nine conserved motifs including ATPase and RNA helicase motifs.
Application
ANTI-BAT1(C-TERMINAL) antibody produced in rabbit has been used in immunoprecipitation and western blotting.
Biochem/physiol Actions
BAT1/ UAP56 facilitates the binding of U2 small nuclear ribonucleoprotein (SnRP) to pre-mRNA. It also helps in the export of mRNA from the nucleus to the cytoplasm. Spliceosome RNA helicase BAT1 is implicated in adapting nucleic acid metabolism to cellular stress. BAT1 is implicated in the down-regulation of inflammation. The gene polymorphism might be associated with the development of allergic diseases such as bronchial asthma, allergic rhinitis, atopic dermatitis, food allergy, drug allergy and pollen allergy. Mutation in the gene may also lead to the development of urticaria and Quincke′s edema.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
R J Allcock et al.
Genes to cells : devoted to molecular & cellular mechanisms, 6(5), 487-494 (2001-05-31)
BAT1 belongs to the DEAD-box family of RNA-binding proteins and is encoded in the central MHC. To determine whether it affects immune responses and hence diseases influenced by MHC haplotypes, U937, THP1 and Jurkat cells were stably transfected with anti-sense
Hang Shi et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(51), 17628-17633 (2004-12-09)
Pre-mRNA splicing requires the function of a number of RNA-dependent ATPases/helicases, yet no three-dimensional structure of any spliceosomal ATPases/helicases is known. The highly conserved DECD-box protein UAP56/Sub2 is an essential splicing factor that is also important for mRNA export. The
M B Freĭdin et al.
Molekuliarnaia biologiia, 45(3), 464-472 (2011-07-28)
Genome-wide association studies are currently considered as one of the most powerful tools to establishing the genetic basis of complex diseases. A number of such studies were carried out for allergic diseases; however, in Russian population this analysis has not
EunMi Juliana Jung et al.
Proteomics, 7(21), 3906-3918 (2007-10-09)
Ambient particulate matter (PM) induces adverse health effects through the ability of pro-oxidative chemicals to induce the production of oxygen radicals and oxidant injury. Utilizing a proteomics strategy involving 2-D DIGE, immunoblotting, and real-time PCR, we demonstrate that organic diesel
Influenza Virus mRNA Trafficking Through Host Nuclear Speckles.
Mor A, et al.
Nature microbiology, 2016 (2016)
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