P5669

Pyridoxine

≥98%

• Synonym(s): Pyridoxol, Vitamin B₆
• Empirical Formula (Hill Notation): C₈H₁₁NO₃
• CAS Number: 65-23-6
• Molecular Weight: 169.18
• EC Number: 200-603-0
• MDL number: MFCD00006335
• UNSPSC Code: 12352104
• PubChem Substance ID: 24898690
• NACRES: NA.28

Properties

• Quality Level: 100
• Assay: ≥98%
• form: powder
• technique(s): HPLC: suitable
• color: white to off-white
• mp: 159-162 °C (lit.)
• SMILES string: Cc1ncc(CO)c(CO)c1O
• InChI: 1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
• InChI key: LXNHXLLTXMVWPM-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544)

Description

General description

Pyridoxine (vitamin B6) is a form of vitamin B6. Other forms include the aldehyde pyridoxal and the amide pyridoxamine. It is an important cofactor for metabolism.[1]

Vitamin B group are water-soluble and exists in six forms which includes the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phospate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate.[2] Vitamin B₆ is distributed in nuts, whole grains and animal meat.[3]

Application

Pyridoxine has been used as a component of:

• artificial diet for sugarcane aphid pest[4]
• modified Strullu and Romand (MSR) medium for carrot root organ culture[5]
• Luria broth for E coli cultures[6]

Pyridoxine is used in cell culture and other applications as a precursor to pyridoxal phosphate. It has been used as a standard in RP-HPLC (reversed phase high performance liquid chromatography) method. Pyridoxine has been used as a diet supplement to study lipid profile in rats.[7]

Biochem/physiol Actions

Pyridoxine plays a key role in cell maintenance and amino acid metabolism.[2] Deficiency of vitamin B₆ leads to anemia especially in pregnant women[8] and seizures in newborns.[3] It serves as cofactor for heme biosynthesis during δ-amino levulinic acid formation[8], γ-aminobutyric acid (GABA) transaminase and glutamic acid decarboxylase.[9] Vitamin B₆ also helps in reactive oxygen species (ROS) scavenging and helps plants in overcoming the abiotic and biotic stress.[10]

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves