P2443

Pluronic^® F-127

powder, BioReagent, suitable for cell culture

• Synonym(s): Non-ionic copolymer surfactant
• Linear Formula: (C₃H₆O·C₂H₄O)x
• CAS Number: 9003-11-6
• MDL number: MFCD00082049
• UNSPSC Code: 12161902
• PubChem Substance ID: 24897874
• NACRES: NA.75

Properties

• description: Non-ionic; contains 100ppm BHT
• product line: BioReagent
• form: powder
• mol wt: ~12600 g/mol
• technique(s): cell culture | mammalian: suitable
• CMC: 950-1000 ppm (~25°C)
• transition temp: cloud point >100 °C
• HLB: 18 - 23
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• InChI key: RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

General description

Pluronicpluronic^® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. It contains polyethylene oxide-polypropylene oxide arranged in a triblock structure to form PEO-PPO-PEO symmetric. Surfactant properties of this polymer derived from its amphiphilic nature, allow them to interact with hydrophobic surfaces and biological membranes.

Application

Pluronic^® F-127 has been used:

• as a delivery system for a peptide to the wound site to study the effect of the peptide on wound healing in mice.
• as a surface coating for PDMS (polydimethylsiloxane) stamps to make them hydrogel repellent.
• in the preparation of calcium indicator stock solution for measuring neural activities.
• as a component of phosphate-buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device.
• This non-ionic copolymer surfactant is suitable for use in insect cell culture applications as an antifoaming agent.

Biochem/physiol Actions

Pluronic^® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. These properties make this polymer suitable for use as a versatile drug carrier.Pluronic^® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. Additionally, it can promote cellular attachment and collagen formation, which facilitates angiogenesis and tissue regeneration. Due to its efficacy, Pluronic F-127 has been utilized in the encapsulation of mesenchymal stem cells (MSCs) to aid in the regeneration of tissues with low levels of vascularity, such as epithelial tissues, adipose tissues, cartilage, tendons, and bone tissues.

Legal Information

Pluronic is a registered trademark of BASF

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves