P2053
pGlu-Glu-Pro Amide
≥97% (HPLC)
Synonym(s):
Fertilization Promoting Peptide
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C15H22N4O6
CAS Number:
Molecular Weight:
354.36
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
NC(=O)C1CCCN1C(=O)C(CCC(O)=O)NC(=O)C2CCC(=O)N2
InChI
1S/C15H22N4O6/c16-13(23)10-2-1-7-19(10)15(25)9(4-6-12(21)22)18-14(24)8-3-5-11(20)17-8/h8-10H,1-7H2,(H2,16,23)(H,17,20)(H,18,24)(H,21,22)
InChI key
HYZBGWLLSXSYLX-UHFFFAOYSA-N
Amino Acid Sequence
Glp-Glu-Pro-NH2
Biochem/physiol Actions
TRH analog that is produced in the thyroid, mammary gland and prostate. Promotes fertilization by enhancing sperm function.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Vien Nguyen et al.
Neuroscience letters, 415(1), 64-67 (2007-01-20)
Local perfusion of pGlu-Glu-Pro-NH2, an endogenous peptide structurally related to thyrotropine-releasing hormone (TRH), via in vivo microdialysis into the rat hippocampus did not change the basal level of extracellular acetylcholine. However, co-perfusion of pGlu-Glu-Pro-NH2 with TRH in equimolar concentrations yielded
K Prokai-Tatrai et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 1(2), 141-152 (2006-06-22)
A metabolically stable and centrally acting analog of pGlu-Glu-Pro-NH2 ([Glu2]TRH, a tripeptide structurally related to TRH (thyrotropin-releasing hormone)) was designed by replacing the amino-terminal pyroglutamyl residue with a pyridinium moiety. The analeptic action of the analog was used to optimize
Albert Eugene Pekary et al.
Brain research, 1125(1), 67-76 (2006-11-23)
This is the first report of diurnal variations in the levels of thyrotropin-releasing hormone-like peptides (pGlu-X-Pro-NH(2), where "X" can be any amino acid residue) in brain regions involved in mood regulation. These peptides have neuroprotective and antidepressant-like properties that may
Katalin Prokai-Tatrai et al.
Bioorganic & medicinal chemistry letters, 13(6), 1011-1014 (2003-03-20)
Potential prodrugs for the TRH-like tripeptide pGlu-Glu-Pro-NH(2) were synthesized either by esterifying the Glu side-chain of the parent peptide in solution with alcohols in the presence of resin-bound dicyclohexylcarbodiimide or by solid-phase peptide chemistry. Affinities of these ester prodrugs to
Lynn R Fraser et al.
Molecular human reproduction, 9(12), 739-748 (2003-11-14)
When placed in a suitable environment, mammalian spermatozoa begin to capacitate and continue until fully capacitated; in vitro, some will 'over-capacitate' and undergo spontaneous acrosome loss, undesirable since acrosome-reacted cells are non-fertilizing. Seminal plasma contains several molecules able to bind
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service