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M3656

Sigma-Aldrich

Mephentermine hemisulfate salt

Synonym(s):

N,α,α-Trimethylphenethylamine hemisulfate salt

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About This Item

Linear Formula:
C11H17N · 1/2H2SO4
CAS Number:
1212-72-2
Molecular Weight:
212.30
EC Number:
214-923-3
MDL number:
MFCD00083413
UNSPSC Code:
12352200
PubChem Substance ID:
24896864

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

SMILES string

OS(O)(=O)=O.CNC(C)(C)Cc1ccccc1.CNC(C)(C)Cc2ccccc2

Biochem/physiol Actions

α-adrenoceptor agonist.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
033K1211
060H0442

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B Bhattarai et al.
JNMA; journal of the Nepal Medical Association, 49(177), 23-28 (2010-12-25)
Hypotension is common following spinal anesthesia. Various vasopressors have been indicated to prevent it. The study compares three such agents namely phenylephrine, ephedrine and mephentermine. The study included 90 patients undergoing elective and emergency cesarean section who developed hypotension following
M Mori et al.
Xenobiotica; the fate of foreign compounds in biological systems, 19(3), 287-299 (1989-03-01)
1. Excretion of urinary and biliary radioactivity, and metabolites of [3H]mephentermine (MP), after i.p. or subcutaneous administration of [3H]MP to male Wistar rats, were determined by preparative t.l.c.-liquid scintillation counting. 2. About 45% of the radioactivity administered i.p. was excreted
M A Mori et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(1), 11-18 (1993-01-01)
1. The N-demethylation of mephentermine (MP), p-hydroxymephentermine (p-hydroxy-MP) and N-hydroxymephentermine (N-hydroxy-MP), to produce phentermine (Ph), p-hydroxyphentermine (p-hydroxy-Ph) and N-hydroxyphentermine (N-hydroxy-Ph), and the p-hydroxylation of MP and Ph, to produce p-hydroxy-MP and p-hydroxy-Ph, were examined using rat liver microsomal preparations containing
M Mohta et al.
Anaesthesia and intensive care, 37(4), 568-570 (2009-08-18)
This study was designed to determine the minimum effective dose (ED50) of mephentermine for prevention of post-spinal hypotension in women undergoing elective caesarean section. Dixon's up-down method of sequential allocation was used to determine the patient's dose of vasopressor drug.
T Murali Krishna et al.
European journal of anaesthesiology, 25(4), 299-306 (2007-09-26)
Intrathecal ketamine produces a short period of analgesia with stable haemodynamics. Midazolam with bupivacaine prolongs the duration of analgesia when administered intrathecally but does not prevent hypotension. The objective of this study was to assess the effect of a combination
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