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About This Item
Empirical Formula (Hill Notation):
C4H9NO4S
CAS Number:
Molecular Weight:
167.18
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (TLC)
storage temp.
−20°C
SMILES string
NC(CCS(O)=O)C(O)=O
InChI
1S/C4H9NO4S/c5-3(4(6)7)1-2-10(8)9/h3H,1-2,5H2,(H,6,7)(H,8,9)
InChI key
PDNJLMZEGXHSCU-UHFFFAOYSA-N
Biochem/physiol Actions
Potent, fast-acting NMDA glutamate receptor agonist.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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W Morishita et al.
Journal of neurophysiology, 82(5), 2556-2564 (1999-11-24)
Depolarization-induced suppression of inhibition (DSI) is a process whereby brief approximately 1-s depolarization to the postsynaptic membrane of hippocampal CA1 pyramidal cells results in a transient suppression of GABA(A)ergic synaptic transmission. DSI is triggered by a postsynaptic rise in [Ca(2+)](in)
H Sugiyama et al.
Neuron, 3(1), 129-132 (1989-07-01)
Three major subtypes of glutamate receptors that are coupled to cation channels are known. Recently an additional subtype that is coupled to G proteins and stimulates inositol phospholipid metabolism (the metabotropic glutamate receptor) has been proposed. The pharmacological characteristics of
M Bouvier et al.
The Journal of physiology, 444, 441-457 (1991-12-01)
1. The effect of sulphur-containing analogues of glutamate and aspartate on the membrane current of glial cells was studied by whole-cell clamping Müller cells isolated from the salamander retina. 2. L-Cysteic acid (CA), L-cysteinesulphinic acid (CSA), L-homocysteic acid (HCA), L-homocysteinesulphinic
Homocysteic acid, an endogenous agonist of NMDA-receptor: release, neuroactivity and localization.
M Cuénod et al.
Advances in experimental medicine and biology, 203, 253-262 (1986-01-01)
Philipp Görtz et al.
Journal of the neurological sciences, 218(1-2), 109-114 (2004-02-05)
Severe hyperhomocysteinemia (50-200 microM) often presents itself with acute neuronal dysfunction including seizures and psychosis. Its moderate form (15-50 microM) is associated with cognitive impairment and dementia. We investigated the neuropharmacological effects of homocysteine and its oxidized forms, homocysteinesulfinic acid
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